Aptar CSP launches Xcelerate development services to fast-track active packaging solutions

  • Aptar CSP Technologies

From stability challenge to commercial launch, Xcelerate expedites packaging process for medicines sensitive to moisture, oxygen and volatile compounds

Aptar CSP Technologies, a leader in material science and active packaging solutions that ensure product protection, extend shelf life, and improve user experiences and part of Aptar Group, Inc., announces the launch of a complete solution service offering focusing on de-risking development and insuring speed-to-market. The new Xcelerate Development Services (“Xcelerate”) optimizes the active packaging development process through end-to-end expert insight, resulting in expedited speed-to-market. Xcelerate was recently awarded the 2019 All-Star Innovator by Pharma Manufacturing Magazine.

Xcelerate combines Aptar CSP Technologies’ unique material science and active packaging solution and associated services with FreeThink Technologies’ leadership in accelerated predictive modeling in shelf-life determination. Utilizing FreeThink’s ASAPprime® technology, an optimized active packaging solution product is modeled and tested without the need for expensive, time-consuming line trials. The result is a “right the first time” approach that virtually eliminates repetitive design processes and reformulations caused by stability test failures.

Aptar CSP Technologies offers a portfolio of services (research and development, clinical and stability studies, commercial planning and production, etc.) built around its proprietary 3-Phase Activ-Polymer™ technology platform, which is delivered in a variety of configurations:

Activ-Blister™ solutions control the internal atmosphere of individual blister cavities. Applied via CSP Technologies’ patented heat-staking process without the use of adhesives, the technology accommodates any tablet and capsule size.

• For bottled medicines, Activ-Seal™ closures incorporate moisture and gas scavenging technology press-fit into an induction-sealed, tamper-evident screw cap.

• The Activ-Vial™ portfolio consists of one-piece, flip-top desiccated vials and desiccated bottles across a range of sizes.

Activ-Film™ was developed to enhance transdermal drug delivery systems (TDDS), which provide controlled delivery of active substances through the skin.

Xcelerate reduces the entire active packaging design, testing and implementation process. The comprehensive, hands-on approach also includes capabilities to produce clinical trial and stability samples, regulatory support, consulting and testing during commercial implementation.

Aptar CSP Technologies launched Xcelerate in response to the increased complexity of matching moisture- and oxygen-sensitive medicines to ideal packaging solutions. As drug companies produce more potent APIs, larger molecules and modified release profiles, there is increased risk for stability issues associated with moisture, oxygen and volatile reactives. Innovative dosage forms such as chewable and disintegrating tablets also face significant shelf life challenges with respect to humidity sensitivity. These products may also face the added challenge of global distribution demands in Climate Zones 3/4b (hot/humid).

Xcelerate’s customized process determines a drug product’s moisture and oxygen sensitivity using highly accelerated stability studies open to specified environmental conditions such as temperature, relative humidity and oxygen level, then uses modeling to create theoretical package designs. Once the optimal packaging sorbent levels are determined, laboratory, clinical and stability study sample supplies can be prepared for confirmation or actual use.

“Our complete solution of material science driven active packaging solutions, and the newly launched Xcelerate Development Services offer improved stability, extended shelf-life and expedited time-to-market for sensitive medicines,” said Craig Voellmicke, Vice President, Business Development, Aptar CSP Technologies. “Together, they provide a valuable combination of effective drug protection and ease of adoption.”

See also

Aptar CSP presents rethinking oral solid dose packaging webinar

Aptar CSP presents 'rethinking oral solid dose packaging' webinar

Aptar CSP Technologies – a leader in active packaging solutions that ensure product protection, enhance brand recognition and improve use experiences, and part of AptarGroup Inc – is presenting its Activ-Blister Solutions for the protection of moisture and oxygen-sensitive tablets and capsules, alongside FreeThink Technologies and its ASAPprime technology for accelerated shelf-life determination. The combination is a “right the first time” approach to stability challenges and blister package design that virtually eliminates protracted testing and costly reformulations.

CSP Technologies focus for enhancing the shelf life for transdermal and oral solid dose drugs

CSP Technologies' focus for enhancing the shelf life for transdermal and oral solid dose drugs

Despite being two very different drug delivery platforms, oral solid doses and transdermal patches can face similar packaging headspace challenges that impact shelf life; besides moisture and oxygen ingress, exposure to certain conditions can lead to the formation of volatile organic compounds (VOCs) and other gases that, in turn, may interact with drug products and capsules, adversely impacting their stability.

  • Jo Webb
  • Product Info
  • English
  • Created 05 Nov 2019
  • Modified 05 Nov 2019
  • Hits 125