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Gerresheimer has assumed responsibility for the industrialization of a dry powder inhaler for the treatment of respiratory ailments for MERXIN (United Kingdom), a company that specializes in making inhaler devices. The inhaler is produced in Pfreimd (Germany) for worldwide distribution. Beyond the technically sophisticated industrialization of the product, the main challenge of the project was to coordinate an optimal development process aimed at ensuring the shortest possible time to market at the lowest cost.
MERXIN MRX003 capsule dry powder inhaler is used for pulmonary delivery and in particular for the treatment of chronic, obstructive pulmonary diseases (COPD) and asthma. The API is aerosolized and distributed with the respiratory system to find its way deep into the lungs of the patient. The correct interplay of inhaler and formulation plays a decisive role in the success of the treatment.
The first product target for MRX003 was a generic version of an API. Because of the nature of the generic market, it was of essential to achieve the shortest possible time to launch. This was achieved through a close cooperation between the partners. Decades of expertise and know-how in inhaler design and production were combined between MERXIN and us.
Jochen Wegerer (Program Manager, Gerresheimer Regensburg GmbH, Wackersdorf) was impressed by the cooperation: “The good teamwork within the project is noteworthy. Challenges were always discussed in a goal-oriented, creative, and open manner, so that approaches to solutions could be formulated and implemented within the shortest time possible.”
The design of the manufacturing process of MRX003, had to deliver high product quality with the most stable, fully automated processes possible and to enable affordable production for the generic drugs market. “With the help of our DMF package, we were able to create, implement, and qualify the molds to be very robust,” Richard Gradl (Mold Engineer, Gerresheimer Regensburg GmbH, Wackersdorf) explains.
“The stable component quality and high process capability of the molds ensure good conditions in the series production environment.” Our risk management approach was based on procedures that were tailored to the special features of the project, from qualification and validation to long-term production security, as highlighted by Tobias Bernklau (Global Head of Quality Engineering, Gerresheimer Regensburg GmbH, Wackersdorf): “The focus is always on the user for all decisions. For critical areas and functions, we deliberately invest more effort than for less critical areas and functions.”
MRX003 is assembled from a total of 12 parts, meaning seven injection molding parts of ABS or MABS (base element, capsule housing, hinge plate, button, mouthpiece, filter housing, sealing cap) as well as five stainless steel bought-in components (two lancets, spring, cylinder pin, and fine filter unit). A pouch is used for the packaging of the finished product. For the BICs, we selected suppliers who are capable of fulfilling sophisticated quality. The injection molding parts are produced at our location in Pfreimd in multi-cavity tools. The fully automated assembly and gap-free testing of each individual inhaler takes place at three round table stations.
Gerresheimer awarded EcoVadis gold for sustainable corporate management
Gerresheimer has been awarded the gold medal for the first time by EcoVadis, one of the leading providers of sustainability rankings, for the successful implementation of its sustainability strategy. With 68 out of a maximum of 100 possible points, Gerresheimer is among the top 5 percent of all companies assessed by EcoVadis and among the best 2 percent in the industry.
Gerresheimer presents sustainable and innovative cosmetic product solutions
Consumers are increasingly taking sustainability aspects into account in their purchasing decisions. The cosmetics industry is a pioneer in sustainable development. At Cosmetic Business, Gerresheimer displays attractive glass flacons and jars made of post-consumer recycled (PCR) glass as well as weight reduced EcoDesign variants.
Covid-19 drug packaged in Gerresheimer's Duma Twist-off containers
The Duma Twist-Off container from the Gerresheimer production facility in Vaerloese, Denmark, was selected as the ideal packaging for a new Covid-19 drug which comes in tablet form. It directly targets the virus and blocks its replication.
EcoLine ensures the most sustainable packaging solution
With EcoLine, Gerresheimer demonstrates criteria in the development and production of its well-known plastic container series for solid and liquid medications which play an important role in designing sustainable packaging solutions and thus contribute to greater environmental compatibility.
Gerresheimer produces the flacon for Baldessarini Signature
Gerresheimer has produced the flacon for Baldessarini Signature on behalf of Mäurer & Wirtz. The heavy, high-quality glass flacon is finished in elegant deep blue and symbolizes simple, stylish and timeless elegance. Its clear, elegant design with a certain extravagance matches the expressive fragrance composition.
Gerresheimer supplies the primary packaging for dexamethasone
Gerresheimer has been commissioned by a well-known customer to produce plastic containers in which the active ingredient dexamethasone is to be filled. According to a study, the active ingredient can reduce the mortality of people who are seriously ill with Covid 19.
EcoVadis: Silver status for Gerresheimer in sustainability audit
In 2018 Gerresheimer succeeded in making the leap from bronze to silver rating with 46 points in the annual EcoVadis evaluation. In 2019 the company improved within this rating to 58 points and is therefore one of the top 6% of companies assessed.
Gerresheimer manufactures sustainable plastic packaging for body care products
Consumers are placing great importance on sustainable products, specifically on sustainable packaging solutions that can be disposed of in an environmentally friendly way. A pioneer in the quest for greater sustainability, Gerresheimer offers an extensive standard range of plastic packaging and devises customized solutions made from PET, R-PET, and BIO-PET plastics.
Gerresheimer reduces development time for glass containers
Glass production begins with engineering the mould. The more accurately the moulds are designed and made, the greater the quality of the bottle. A perfect and even distribution of glass is the key to success when it comes to ensuring the robustness and sustainability of these highly sensitive products. Gerresheimer employs innovative simulation software for this purpose.
Gerresheimer is driving sustainable cosmetic glass packaging by using more post-consumer recycled glass
As a leading producer of glass packaging for cosmetic products, Gerresheimer is committed to driving sustainability in the sector. Gerresheimer has been successfully producing glass with a high proportion of post-consumer recycled (PCR) material for over 10 years in Momignies, Belgium.
Glass packaging as an integral style element
"People buy scent with their eyes,” says Bernd Stauch, Senior Director Sales Cosmetics at Gerresheimer. Gerresheimer’s new high-performance Decoration Centers at Momignies in Belgium and Tettau in Germany employ the latest technology such as UV printing, to ensure that perfume products look as good as they smell.
Gerresheimer maximises its decoration potential
Gerresheimer’s factories in Tettau (Germany) and Momignies (Belgium) specialize in the industrial production of cosmetic glass and have been supplying notable customers in the cosmetics industry for decades. At both sites, newly created, high-performance “Decoration Centers” use modern techniques to customize sophisticated branded products for the cosmetics market.
Gerresheimer's Gx Elite vials help ensure patient safety
With its Gx Elite and Gx RTF vials, Gerresheimer presents two new type I vials made from borosilicate glass. The Gx Elite vials are the result of a careful product development process spanning several years. The highly shatter-resistant vials are extremely durable, free of cosmetic defects and can be customized for specialized customer requirements.
Gerresheimer is investing in a new plant in Skopje, North Macedonia, for medical plastic systems and syringes
Gerresheimer is investing a mid-double-digit million Euro figure in the new plant in the North Macedonian capital of Skopje, an amount that is already included in the company’s medium-term investment plans. Construction is beginning in the first half of 2019, with completion scheduled for the first half of 2020. It is expected that start of production will take place in the second half of 2020.
Gerresheimer to expand its services to include irradiation of plastic dropper bottles used in ophthalmology and rhinology
Gerresheimer will use this year's Pharmapack held in Paris, Porte de Versailles, as a platform to unveil their latest ophthalmology and rhinology services at booth B62. The company has teamed up with select certified partners to add surface finishing of plastic dropper bottles to their irradiation services.
Gerresheimer increases revenues by 8.8% and successfully integrates Sensile Medical
The Gerresheimer Group increased revenues at constant exchange rates by 8.8% in the third quarter of 2018, from EUR 335.0m in the prior-year quarter to EUR 364.4m. This includes EUR 3.5m from Sensile Medical, which was acquired in July 2018. On an organic basis—meaning adjusted for exchange rate effects and Sensile Medical—revenues went up by 7.8% relative to the prior-year quarter.
Gerresheimer's Duma Pocket fits through many mailboxes
Gerresheimer's handy Duma Pocket tablet containers are well-known for being drugs containers that fit into any bag. Because they are oval, they don't take up much space. Another great feature is that it can't open itself when it's inside a bag. It’s irritating when this happens and the tablets become loose. This is also beneficial when sending the product to users in the mail.
Gerresheimer extends business model and increases growth forecast
Gerresheimer is acquiring Swiss technology company Sensile Medical AG and thus fundamentally extends its business model. The acquisition enables Gerresheimer to offer drug delivery platforms with digital and electronic capabilities for pharmaceutical and biopharmaceutical customers.
CPhI China 2017: Gerresheimer boosts its presence in Asia and unveils new packaging solutions
The Asian market is a key priority for Gerresheimer. With a total of seven production sites in China and India, the company boasts an excellent basis for manufacturing pharmaceutical packaging from glass and plastic.
Cosmetics packaging – Gerresheimer provides persuasive evidence through the appeal of glass
Gerresheimer belongs to the leading worldwide suppliers of glass for cosmetics. The company offers its visitors on May 10 and 11 at Luxepack 2017 in New York and at Beautyworld Middle East on May 14 up to 17 in Dubai the latest highlights out of enchanting new glass containers.
- Jo Webb
- Brand Launch
- Created 13 Nov 2022
- Modified 14 Nov 2022
- Hits 292