Consumer preference and brand team desires for differentiation are driving manufacturers to remove preservatives from formulations, because they can create adverse reactions in many patients. The side effects of preservatives often include irritation of the nasal passages, nose bleeds, allergic reactions and tissue thinning or damage – particularly a concern with chronic medication usage. Our quantitative research has shown that 80% of patients prefer preservative-free medications, and they are often willing to pay more for them. The research also found that the vast majority of physicians and pharmacists prefer prescribing/recommending preservative-free medications.