Multiparticulate System Formulation Development

Multiparticulate drug delivery systems are primarily oral dosage forms consisting of multiple small discrete units, each exhibiting some desired characteristics. In these systems, the drug dose is divided over multiple subunits, usually consisting of thousands of spherical particles with a diameter of 0.05-2.00 mm. The multiparticles are less dependent on gastric emptying, resulting in lower inter- and intra-subject variability in gastrointestinal transit times. They are also better distributed and less likely to cause local sensitization.